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KMID : 1199120090330060503
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Korean Diabetes Journal
2009 Volume.33 No. 6 p.503 ~ p.510
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The Cutoff Value of HbA1c in Predicting Diabetes in Korean Adults in a University Hospital in Seoul
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Pae Ji-Cheul
Park Cheol-Young
Oh Ki-Won
Park Sung-Woo
Kim Ji-Hoon
Lee Won-Young
Kim Sun-Woo
Rhee Eun-Jung
Kim Won-Jun
Park Se-Eun
Yoo Seung-Hyun
Choi Eun-Suk
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Abstract
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Background: Glycated hemoglobin (HbA1c) levels represent a 2~3 month average of blood glucose concentration. The use of HbA1c as a diagnostic tool for diabetes is gaining interest. Therefore, we determined the cutoff point of HbA1c for predicting abnormal glucose tolerance status in non-diabetic Korean subjects.
Methods: We analyzed the data from 1,482 subjects without diabetes mellitus in whom a 75-g oral glucose tolerance test (OGTT) was performed due to suspected abnormal glucose tolerance. We obtained an HbA1c cutoff point for predicting diabetes using Receiver Operating Characteristic (ROC) curve analysis.
Results: A cut-off point of 5.95% HbA1c yielded sensitivity of 60.8% and specificity of 85.6%, respectively, for predicting diabetes. There was a difference in HbA1c cut-off value between men and women, 5.85% and 6.05%, respectively.
Conclusion: To use the cut-off point of 5.95% HbA1c for predicting undiagnosed diabetes in Koreans may be reliable. However, studies of different ethnic groups have reported disparate HbA1c cut-off points. Thus, ethnicity, age, gender, and population prevalence of diabetes are important factors to consider in using elevated HbA1c value as a tool to diagnose diabetes.
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KEYWORD
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Diabetes mellitus, Diagnosis, Glycated hemoglobin A1c
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